Ovasitol Plus vs Ovasitol: A PCOS Dietitian’s Review

Have you heard about Ovasitol Plus? This supplement is like the new kid sister to the OG holy grail PCOS supplement Ovasitol. Now, you may be wondering if you’re better off trying Ovasitol Plus and if it’s worth the higher price tag. 

As a registered dietitian who specializes in PCOS, I’m going to give you the lowdown on this new supplement. This blog post will talk about what Ovasitol Plus is, the difference between Ovasitol Plus and Ovasitol, and how to decide which one is best for you.  

What is Ovasitol Plus?

Ovasitol Plus is a new supplement made by the US company Theralogix. It’s described as a Metabolic Health supplement and the packaging looks extremely similar to the original Ovasitol supplement. 

Ovasitol Plus is an inositol supplement with some added nutrients inside of it. It contains the research-backed 40:1 ratio of myoinositol to d chiro inositol, plus vitamin D, chromium, and alpha-lactalbumin. 

At this time, Ovasitol Plus only comes in individual serving packets. The recommended serving size is to take one packet twice per day. So you’ll ultimately be taking two packets daily. 

In each daily dose of Ovasitol Plus (2 packets), you’ll be getting: 

• 4000 mg myo-inositol
• 100 mg d-chiro-inositol
• 100 mg alpha-lactalbumin
• 1000 IU vitamin D3
• 200 mcg chromium picolinate 

Similar to Ovasitol, Ovasitol Plus undergoes third-party testing by NSF International to ensure quality and purity.

Let’s talk about what the difference between Ovasitol Plus and the traditional Ovasitol supplement are. Then we’ll dive into how you decide which one is right for you. 

What’s The Difference Between Ovasitol and Ovasitol Plus? 

Alright, if you’re wondering what the heck the difference is between Ovasitol and Ovasitol Plus, let’s dive into it. 

Ovasitol

Ovasitol is the original inositol supplement made by the brand Theralogix. It contains two different types of inositol: myo-inositol and d-chiro-inositol. These two types of inositol are found in a 40:1 ratio of myo-inositol to d-chiro inositol, which is the same inositol ratios that’s naturally found in our bodies’ tissues. 

Inositol is one of the most well-studied supplements for PCOS management. Read more about the potential benefits of an inositol supplement here: 12 Benefits of Ovasitol for PCOS.

According to research studies, inositol can help to: 

• Lower glucose and insulin levels
• Reduce body weight
• Decrease cholesterol levels
• Reduce carb cravings
• Improve thyroid function
• Lower testosterone levels
• Regulate your menstrual cycle 
• Improve egg quality
• Improve IVF outcomes
• Decrease gestational diabetes risk

Pretty impressive, right? Ovasitol is safe for long-term use and can also be combined with other prescription medications commonly prescribed for PCOS such as Metformin and birth control pills. It’s also considered safe to continue during pregnancy and while breastfeeding.

Potential side effects of Ovasitol are rare but may include hypoglycemia (low blood sugar levels). The risk of hypoglycemia is higher if you’re also taking Metformin or other medications that may lower your blood sugar. A small number of people also report digestive issues or headaches.

Ovasitol Plus

Ovasitol Plus contains the same ingredients as the original Ovasitol powder, plus a few additional nutrients. In addition to the 40:1 myoinositol and d-chiro inositol blend, Ovasitol Plus also contains: vitamin D, chromium, and alpha-lactalbumin.

Since we already talked about the benefits of regular Ovasitol, let’s talk about the other additional nutrients in Ovasitol Plus. 

Besides the same myo-inositol and d-chiro-inositol combination, Ovasitol Plus also contains: 

• 100 mg alpha-lactalbumin
• 1000 IU vitamin D3
• 200 mcg chromium picolinate

Let’s talk about each of these ingredients a bit more. 

Alpha-Lactalbumin

Alpha-lactalbumin is a whey protein found in milk, particularly in human breastmilk and cow’s milk. It’s rich in essential amino acids and has several potential health benefits. It has been studied for its ability to enhance nutrient absorption while also improving gut health and immune health.

There have been a few recent studies that found alpha-lactalbumin can enhance myo-inositol absorption (1). One small study found that 62% of PCOS women ovulated after being treated with 4000 mg of myo-inositol for 3 months. The other 38% were resistant to this dose of myo-inositol and did not ovulate. For the next 3 months, the 38% who were inositol-resistant were given 4000mg myo-inositol plus 100mg alpha-lactalbumin daily. After this 3 month period with the combination treatment, 86% of those PCOS women ovulated. 

This is pretty promising info! If you’ve ever tried Ovasitol and felt like you’re not getting the stellar results that others talk about, you may be one of the ones who are resistant to inositol and may benefit from the addition of alpha-lactalbumin to increase absorption. 

One thing to note though is that alpha-lactalbumin is a protein from cow’s milk. If you have a milk protein allergy or intolerance, you should avoid this. 

Vitamin D3

Here’s a mindblowing fact: up to 85% of people with PCOS are vitamin D deficient. Wild, right?!

It kind of makes sense. Even though vitamin D is commonly thought of as a vitamin, it’s actually a hormone. It’s found in different foods such as salmon, egg yolks, and fortified dairy products, however, it’s usually difficult to get enough vitamin D from food alone. 

Research has shown that having optimal levels of vitamin D can: 

• Improve menstrual regularity
• Increase ovulation rates and the amount of mature follicles
• Decrease insulin resistance and glucose levels
• Lower inflammation
• Decrease testosterone levels (2)

Vitamin D levels can easily be checked through lab work…and I highly recommend that you have them checked at least yearly if you have PCOS. Since it’s difficult to get enough vitamin D from food sources or the sun, most people with PCOS can benefit from vitamin D supplementation daily. The amount you need will vary, especially if your levels are low.

Ovasitol Plus provides 1000 IU vitamin D daily. This may be enough vitamin D for some people with PCOS. However, if your levels are low, you’ll likely need an additional vitamin D supplement. 

Chromium Picolinate

Chromium is an essential trace mineral that’s naturally found in several different foods and also available as a dietary supplement. 

Research has found that chromium supplementation can help to: 

• Lower insulin levels
• Decrease body weight and BMI
• Lower testosterone levels
• Decrease inflammation
• Lower cholesterol levels

Clinical studies have used a dose range between 200 to 1000 mcg of chromium picolinate supplements daily. Most studies did report benefits with the lower dose of 200 mcg of chromium picolinate. Ovasitol Plus contains 200mcg of chromium picolinate in a daily serving so you likely can expect to see some of these benefits. 

Side effects of chromium supplements tend to be rare but it could cause nausea, upset stomach, headaches, insomnia, or mood changes. Those with liver or kidney issues, or who are pregnant or breastfeeding should exercise caution and avoid chromium supplements until they talk to their healthcare provider.

Read more about the benefits of chromium for PCOS here.

Is Ovasitol Plus Better than Regular Ovasitol?

Imagine you’re trying to unlock a door with a standard key. For most people, the key fits perfectly, and the door opens with no problem. But for some people, their lock is a little stiff or slightly different—so just using the key isn’t enough.

Those people might need a little extra help. They may need to wiggle the key around or push the door slightly to get it to open. The key (inositol) is still the right tool, but some people (inositol-resistant individuals) need an extra boost (like alpha-lactalbumin) to make it work properly.

So for the vast majority of people, traditional Ovasitol is just fine and can deliver really impressive benefits. For some people though, Ovasitol Plus can be what they need to get those same impressive benefits. 

How Do I Know If I Need Ovasitol Plus? 

Most people should do a 3 month minimum trial of traditional Ovasitol first before they consider Ovasitol Plus. If you’ve tried Ovasitol and aren’t impressed with the results, then you may want to consider trialing Ovasitol Plus. 

It’s important to know though that Ovasitol Plus is not considered to be safe for pregnancy or if you’re breastfeeding. According to the Theralogix website: once a pregnancy is confirmed, you should stop Ovasitol Plus and switch to original Ovasitol. This is because Ovasitol Plus contains 200 mcg of chromium picolinate per daily dose (two packets), and chromium supplements are not recommended during pregnancy. If you are trying to conceive through IVF, switch to Ovasitol after your embryo transfer. If you are trying to conceive through IUI, switch to Ovasitol after your insemination.

Cost of Ovasitol Plus vs Alternatives

If the price tag of Ovasitol Plus has you second guessing it, I hear you. PCOS supplementation is not cheap unfortunately – especially if you’re looking at purchasing quality supplements like Ovasitol or Ovasitol Plus. 

One package of Ovasitol Plus with a PRC discount code will cost you just under $100 USD. This will last you 3 months if you take the recommended higher dose of 2 packets per day, or 6 months if you take just one packet per day.

While this cost is steep, it works out to be a lot more affordable than some competitors in the long run. Let me break it down. 

The cost of Ovasitol Plus is $97.65 for a 3 month supply. If you were to try to replicate the same ingredients in other supplements, you’ll need to find:

• 4000 mg myo-inositol
• 100 mg d-chiro-inositol
• 100 mg alpha-lactalbumin
• 1000 IU vitamin D3
• 200 mcg chromium picolinate

Myo-Inositol + D-Chiro-Inositol Alternatives

A 90 day supply of inositol alternatives could cost:

• Traditional Ovasitol: $73.68 USD for the canister or $87.37 USD for the individual packets.
• Wholesome Story powder: $155.70 USD. Many people think this option is more affordable, which it is at face value. When you start to look at the dose though, you’ll realize it’s only half of what Ovasitol provides. It costs $25.95 for 30 servings of 2000 mg myo-inositol and 50 mg d-chiro inositol. If you were to double the dose as recommended, the price would double.
• Wholesome Story capsules: $129.90 USD for the equivalent dose to Ovasitol. 

Alpha-Lactalbumin Alternatives

Alpha-lactalbumin cannot be purchased as an individual supplement. Since it’s a whey protein found in milk, you could get an ample amount of alpha-lactalbumin from one serving of whey protein isolate powder. An added bonus of doing this is that you get more protein into your diet – but it obviously increases your out of pocket cost significantly. 

Here are two whey protein isolate powders that I like:

• Garden of Life Whey Protein Isolate: $41.95 for 12 servings or $314.63 for a 3 month supply.
• Naked Whey Isolate: $45.99 for 28 servings or about $137.97 for a 3 month supply.

Read more about the benefits of protein for PCOS here.

Chromium Picolinate + Vitamin D3 Alternatives

These are relatively affordable supplements.

• NOW Chromium Picolinate: $5.09 USD for a 3 month supply
• Thorne Vitamin D3: $14.00 for a 3 month supply

When you add all of these alternatives up, it would easily cost you double to triple the amount than if you had just purchased Ovasitol Plus.

The Bottom Line

Ovasitol Plus is a newer dietary supplement made by the US based company Theralogix. It’s a combination of the same ingredients in the original Ovasitol supplement, myo-inositol and d-chiro inositol, plus additional nutrients such as alpha-lactalbumin, vitamin D3, and chromium picolinate. 

The added nutrients in Ovasitol Plus can enhance absorption of inositol, especially in those with PCOS who are inositol-resistant. It also can increase the effects by providing more support for healthy blood sugar and insulin sensitivity, regular menstrual cycles and ovulation, and lower inflammation and testosterone levels. 

Ovasitol Plus may be a good option for someone who has not responded effectively to traditional Ovasitol, or, for someone who wants additional metabolic support. One thing to note though is that alpha-lactalbumin is a protein from cow’s milk. If you have a milk protein allergy or intolerance, you should avoid Ovasitol Plus. 

Unlike Ovasitol, Ovasitol Plus is not considered safe for pregnancy or breastfeeding. If you are taking Ovasitol Plus and do become pregnant, it’s recommended to switch to Ovasitol. 

If you’re interested in trying Ovasitol or Ovasitol Plus, it can be ordered directly through the Theralogix website using PRC 202702 for a discounted rate. Don’t forget to also check out my other Favorite Theralogix Supplements for PCOS.

Other PCOS Supplements Info To Not Miss

Best Multivitamin for PCOS: Do You Need One?

Vitamin B12 for PCOS: Benefits & Recs

Berberine vs Inositol for PCOS? Or Both?

Maca Root for PCOS: Does It Work?

Disclaimer: this is for informational purposes only. It is not intended to substitute for or replace professional medical advice for polycystic ovarian syndrome (PCOS) or any other medical condition. Do not start or stop any dietary supplements without professional medical advice. Always speak to your medical doctor or healthcare team regarding your unique medical needs.